An unemployed, panhandling, college dropout named Vinny, living in his mom and step-dad's basement, applies for a janitor position at the local hospital after he meets a beautiful nurse. Life gets flipped upside down when his idiot friend hacks the computer and he mistakenly gets hired as an emergency room trauma surgeon. Love, sex and hilarious mayhem ensue during his quest to remain employed so he can win the girl's affection.